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目的探讨地塞米松对乙型脑炎患儿的病情、预后及脑脊液α-肿瘤坏死因子(TNF-α)与干扰素(IFN)的影响。方法把33例重型极期乙脑患儿随机分为两组,地塞米松组18例给予静脉地塞米松针4～5d;对照组15例则不用地塞米松。观察比较两组的临床过程和脑脊液TNF-α与IFN的变化。结果入院时两组的主要临床特点和脑脊液TNF-α与IFN的水平相似,4～5d后地塞米松组的临床症状改善情况优于对照组,但两组的脑脊液TNF-α与IFN的水平却无明显改变,并经过一个月的观察地塞米松组的恢复期症状发生率也低于对照组。结论对重型极期乙脑患儿给予静脉地塞米松可以改善病情,减轻症状,减少恢复期症状的发生。
Objective To investigate the effect of dexamethasone on the severity and prognosis of children with Japanese encephalitis (JE) and the effects of TNF-α and interferon (IFN) on cerebrospinal fluid. Methods Thirty-three patients with severe EEG were randomly divided into two groups. Dexamethasone group was given intravenous dexamethasone for 4-5 days. In the control group, dexamethasone was not used in 15 cases. The clinical course of treatment and the changes of cerebrospinal fluid TNF-α and IFN were observed and compared. Results The main clinical features of both groups at admission were similar to those of cerebrospinal fluid (TNF-α) and IFN. The improvement of clinical symptoms in dexamethasone group was better than that of control group after 4 ~ 5 days. However, the levels of TNF-α and IFN in cerebrospinal fluid But no significant change, and after a month of observation dexamethasone group, the recovery rate of symptoms is also lower than the control group. Conclusion Intravenous dexamethasone given to children with severe extreme Encephalitis can improve the symptoms, relieve the symptoms and reduce the symptoms during recovery.