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目的研究分析依达拉奉对心脏骤停患者血清TNF-α、IL-1β、IL-10及脑功能指标的影响。方法选择2013年12月—2015年7月治疗的心脏骤停患者84例,随机分成两组,各42例。对照组:心肺复苏后没有接受任何药物治疗。观察组:心肺复苏后应用依达拉奉治疗。比较两组复苏不同时段炎性指标血清TNF-α、IL-1β、IL-10水平的变化,同时对比两组患者脑功能的恢复情况。结果复苏后6、12、24、48、72 h,观察组患者TNF-α、IL-1β的水平均低于对照组,而IL-10水平高于对照组,差异具有统计学意义(P<0.05)。用药后,观察组患者脑功能恢复情况优于对照组患者的脑功能恢复情况,其中脑功能分级为1级的比例分别占47.6%和28.6%,差异具有统计学意义(P<0.05)。结论依达拉奉在心脏骤停患者的抢救治疗中具有重要应用价值,能够显著减轻患者的炎症反应,促进患者脑功能的恢复。
Objective To study the effect of edaravone on serum TNF-α, IL-1β, IL-10 and brain function in patients with cardiac arrest. Methods 84 patients with cardiac arrest who were treated from December 2013 to July 2015 were randomly divided into two groups (n = 42 in each group). Control group: CPR did not receive any medication. Observation group: Edaravone treatment after cardiopulmonary resuscitation. The changes of serum TNF-α, IL-1β and IL-10 levels in inflammatory index at different time points were compared between the two groups, and the recovery of brain function was compared between the two groups. Results At 6, 12, 24, 48 and 72 h after resuscitation, the levels of TNF-α and IL-1β in the observation group were lower than those in the control group, while the levels of IL-10 in the observation group were higher than those in the control group (P < 0.05). After treatment, the recovery of brain function in observation group was better than that in control group. The grade of brain function classification was 47.6% and 28.6% respectively, the difference was statistically significant (P <0.05). Conclusion Edaravone has important application value in the rescue treatment of patients with cardiac arrest, can significantly reduce the patient’s inflammatory response, and promote the recovery of patients with brain function.