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目的探讨孕妇外周血胎盘生长因子(PLGF)及促红细胞生成素(EPO)与子痫前期的发病关系。方法用ELISA方法测定外周中PLGF、EPO水平,并记录胎儿出生体重,分析其与子痫前期的关系。结果子痫前期患者外周血PLGF的表达均明显的低于对照组(P<0.05),且与疾病的严重程度相一致;子痫前期患者外周血EPO的表达均明显的高于对照组(P<0.05),且与疾病的严重程度相一致。结论孕妇血PLGF水平、EPO与子痫前期病情呈相关性,PLGF、EPO参与子痫前期的发生发展,研究PLGF、EPO可能为子痫前期的早期诊断和治疗提供新的方法。
Objective To investigate the relationship between placenta growth factor (PLGF), erythropoietin (EPO) and the pathogenesis of preeclampsia in pregnant women. Methods Peripheral PLGF and EPO levels were measured by ELISA. The birth weight of the fetus was recorded and its relationship with preeclampsia was analyzed. Results The expression of PLGF in peripheral blood of patients with preeclampsia was significantly lower than that of the control group (P <0.05), and was consistent with the severity of the disease. The expression of EPO in peripheral blood of patients with preeclampsia was significantly higher than that of the control group (P <0.05), and consistent with the severity of the disease. Conclusions PLGF and EPO levels in pregnant women are correlated with preeclampsia. PLGF and EPO play a role in the development of preeclampsia. It is suggested that PLGF and EPO may provide new methods for the early diagnosis and treatment of preeclampsia.