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目的探讨氯吡格雷联合阿司匹林治疗社区老年冠心病治疗效果改善情况以及服药安全性。方法 120例患者随机分为两组,观察组患者在常规治疗的基础上服用氯吡格雷(75mg/d,1次/d),阿司匹林(0.1mg,1次/d);对照组患者仅口服阿司匹林(0.1mg,1次/d)。比较患者服药期间的心绞痛发作频率、持续时间和硝酸甘油用量,以及患者不良反应和心电图情况。结果观察组心绞痛改善有效率(90.0%)显著高于对照组(78.3%),比较差异具有统计学意义(P<0.05);并且观察组心电图疗效有效率(78.3%)显著高于对照组(63.3%),比较差异具有统计学意义(P<0.05)。以及观察组患者心绞痛频率、硝酸甘油用量、心电图缺血时间和次数均显著少于对照组,两组比较差异具有统计学意义(P<0.05)。在服药过程,两组患者均未见严重的不良反应,轻微不良反应发生率,两组比较差异无统计学意义(P>0.05)。结论氯吡格雷联合阿司匹林治疗老年冠心病心绞痛疗效确切,可以明显改善患者的心绞痛和心电图状况,并且安全性高,值得临床广泛应用推广。
Objective To investigate the effect of clopidogrel combined with aspirin in the treatment of elderly patients with coronary heart disease in community and medication safety. Methods One hundred and twenty patients were randomly divided into two groups. Patients in the observation group were given clopidogrel (75mg / d, once daily) and aspirin (0.1mg once daily) on the basis of conventional treatment. The patients in the control group were orally Aspirin (0.1 mg, 1 time / d). Patients were compared during angina pectoris frequency, duration and amount of nitroglycerin, as well as adverse reactions and ECG patients. Results The improvement rate of angina pectoris (90.0%) in observation group was significantly higher than that in control group (78.3%) (P <0.05), and the effective rate of electrocardiogram (78.3%) in observation group was significantly higher than that in control group 63.3%), the difference was statistically significant (P <0.05). The frequency of angina pectoris, the amount of nitroglycerin, the time and frequency of ECG ischemia in the observation group were significantly less than those in the control group. There was significant difference between the two groups (P <0.05). During medication, no serious adverse reactions and mild adverse reactions were found between the two groups. There was no significant difference between the two groups (P> 0.05). Conclusion Clopidogrel combined with aspirin in the treatment of angina pectoris in elderly patients with definite curative effect can significantly improve the angina pectoris and electrocardiogram in patients with high safety and is worth popularizing widely in clinic.