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近年来,许多学者已普遍注意到甾体肟类化合物作为避孕药使用的可能性。特别是有人提出甾体 C-3位被肟基取代后具有和母体化合物不同的生物活性,可作房事后避孕药或抗着床药使用。然而这一设想究竟是否可行,本文根据现已发表的有关文献进行评论。初期研究中,合成了六种在 C-3位上带有肟基团的孕酮类化合物。发现孕激素活性最强的是6α-甲基-17α-醋酸孕酮肟。但由于17α-醋酸孕酮衍生物具有一定的毒性,因此将兴趣转向19-去甲睾酮类甾体化合物。在
In recent years, many scholars have generally noticed the possibility of using steroidal oximes as contraceptives. In particular, it was suggested that steroid C-3 after the hydroxy-substituted with the parent compound with different biological activity, can be used for post-partum contraceptives or anti-implantation drug use. However, whether this idea is feasible or not is based on the published literature. In the initial study, six progesterone compounds with oxime groups at the C-3 position were synthesized. The most potent progestin was found to be 6α-methyl-17α-progesterone oxime. However, due to the toxicity of the 17 [alpha] -acetophenone derivatives, there has been a shift in interest to 19-nor-testosterone-like steroids. in