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目的探讨高海拔地区老年糖尿病肾病患者同型半胱氨酸(homocysteine,Hcy)的水平,探讨血清Hcy升高的意义。方法采用随机对照方法,根据不同程度的糖尿病肾病患者(早期肾病、临床肾病、尿毒症期)及无肾病的糖尿病患者,比较分析160例老年人Hcy的水平。结果糖尿病肾病患者的Hcy的水平增高,3组不同尿白蛋白排泄率(UAER)糖尿病病人间的Hcy水平,差异有统计学意义(P﹤0.05);Hcy与UAER呈显著正相关(P﹤0.01)。结论 Hcy的水平和糖尿病肾病患者的肾功能损害程度相关,对高Hcy血症的干预治疗,可延缓糖尿病肾病的进展。
Objective To investigate the level of homocysteine (Hcy) in elderly patients with diabetic nephropathy at high altitude and to explore the significance of elevated serum Hcy. Methods A randomized controlled trial was conducted to compare Hcy levels in 160 elderly patients with diabetic nephropathy (early stage nephropathy, clinical nephropathy, uremia stage) and those without nephropathy. Results The level of Hcy in patients with diabetic nephropathy was significantly higher than that in patients with UAER (P <0.05). There was a significant positive correlation between Hcy and UAER (P <0.01) ). Conclusion The level of Hcy is related to the degree of renal dysfunction in patients with diabetic nephropathy. Intervention treatment of hyperhomocysteinemia can delay the progression of diabetic nephropathy.