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DCC基因是大肠肿瘤相关的抑癌基因，位于18号染色体（18q21-qter）上．用抗DCC单克隆抗体（Ab－1）对85例大肠肿瘤作免疫组织化学染色．结果显示DCC基因产物在大肠肿瘤组织中表达有两个特点：①大肠肿瘤细胞对抗DCC单克隆抗体呈阴性反应；②大肠肿瘤间质呈阳性反应。大肠腺癌间质DCC反应阳性率为82％，高于大肠腺瘤（12／23，52％），X2检验P＜0．01．在大肠腺癌中，伴有淋巴结转移或远处转移的肿瘤间质DCC反应阳性率为90％，高于不伴转移者（16／23，70％）Fisher’sexact检验P＜0．05．
DCC gene is a tumor suppressor gene associated with colorectal tumors and is located on chromosome 18 (18q21-qter). Anti-DCC monoclonal antibody (Ab-1) was used to immunohistochemically stain 85 cases of large intestine tumors. The results showed that the expression of DCC gene product in colorectal tumors has two characteristics: 1The colorectal tumor cells showed a negative reaction against DCC monoclonal antibody; 2The colorectal tumor stroma positive reaction. The positive rate of colorectal adenocarcinoma interstitial DCC reaction was 82%, higher than that of colorectal adenoma (12/23, 52%), X2 test P<0.01. In colorectal adenocarcinoma, the positive rate of DCC reaction in tumor interstitial with lymph node metastasis or distant metastasis was 90%, higher than that in non-metastasis (16/23, 70%) Fisher’s exact test P<0.05.