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目的评价FOLFOX4方案治疗进展期结直肠癌的疗效和毒性。方法奥沙利铂(艾克博康)130mg/m2,静滴6h,d1;亚叶酸钙(CF)200mg/m2,静滴2h,d1～5,5-Fu300mg/m2,静滴4h,d1～d5,CF滴完后使用。每21d为一周期,化疗3～6周期后进行疗效分析。结果全组52例患者,总有效率(CR+PR)为44.23%,主要毒副反应为外周神经感觉异常、骨髓抑制、恶心呕吐和腹泻,多为Ⅰ～Ⅱ度。结论FOLOX4方案治疗进展期结直肠癌疗效高,毒副反应可以耐受。
Objective To evaluate the efficacy and toxicity of FOLFOX4 regimen in the treatment of advanced colorectal cancer. Methods Oxaliplatin (Ickaban) 130mg / m2, intravenous infusion 6h, d1; leucovorin (CF) 200mg / m2, intravenous drip 2h, d1 ~ 5,5-Fu300mg / d5, CF after use. Every 21d for a cycle, chemotherapy 3 to 6 cycles after the efficacy analysis. Results The total effective rate (CR + PR) was 44.23% in 52 patients. The main toxicities were peripheral sensory abnormalities, myelosuppression, nausea and vomiting and diarrhea, mostly grade Ⅰ ~ Ⅱ. Conclusion The FOLOX4 regimen is effective in treating advanced colorectal cancer and can tolerate toxic and side effects.