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目的:观察去氨加压素联合温肾健脾中药治疗小儿遗尿的临床疗效,为临床治疗方案的选择提供参考。方法:选取在医院就诊的小儿原发性遗尿患儿168例,随机分为观察组和对照组各84例。对照组单纯采用去氨加压素口服治疗,观察组在对照组治疗方案的基础上,在服用去氨加压素第2个月后开始服用温肾健脾中药,以治疗4个月为1个疗程。对比两组患儿治疗第2个月和治疗第4个月遗尿次数的变化情况,同时对比两组患儿的临床疗效和随访过程中病情复发的情况。结果:经过治疗后,观察组的痊愈率为77.38%,有效率为16.67%,总有效率为94.05%,对照组的痊愈率为60.71%,有效率为17.86%,总有效率为78.57%。观察组的痊愈率和总有效率均显著高于对照组,差异有统计学意义(P<0.05);治疗2个月后,观察组的遗尿次数为(3.21±1.04)次,对照组的遗尿次数为(3.14±1.12)次。两组患儿的遗尿次数均显著少于治疗前(均P<0.05);治疗4个月后,观察组的遗尿次数为(1.32±0.46)次/周,对照组的遗尿次数为(2.47±0.71)次/周,观察组的遗尿次数显著少于对照组,差异有统计学意义(P<0.05);经过3个月的随访,观察组有10例患儿病情复发,复发率为11.90%,对照组有23例患儿病情复发,复发率为27.38%。观察组患儿的复发率显著低于对照组,差异有统计学意义(P<0.05)。结论:去氨加压素联合温肾健脾中药能够有效减少小儿遗尿患儿遗尿的次数,具有良好的临床疗效,同时停药后的复发率较低,具有较好的临床应用价值。
Objective: To observe the clinical efficacy of desmopressin combined with Wenshen Jianpi Chinese medicine in the treatment of children with enuresis, and provide reference for clinical treatment options. Methods: A total of 168 children with primary enuresis in hospital were selected and randomly divided into observation group and control group with 84 cases each. The control group was treated with desmopressin alone. On the basis of the treatment regimen in the control group, the observation group started taking Wenshen Jianpi Chinese medicine twice a month after taking desmopressin, and the treatment group was treated for 4 months as 1 A course of treatment. The changes of the number of enuresis in the second month and the fourth month of treatment in both groups were compared. The clinical efficacy and relapse of the two groups were also compared. Results: After treatment, the cure rate of the observation group was 77.38%, the effective rate was 16.67%, the total effective rate was 94.05%. The cure rate of the control group was 60.71%, the effective rate was 17.86% and the total effective rate was 78.57%. The cure rate and total effective rate in the observation group were significantly higher than those in the control group (P <0.05). After 2 months of treatment, the number of enuresis in the observation group was (3.21 ± 1.04) times and in the control group, The number of times was (3.14 ± 1.12) times. The number of enuresis in both groups was significantly less than that before treatment (all P <0.05). After 4 months of treatment, the number of enuresis in the observation group was (1.32 ± 0.46) times per week, while that in the control group was (2.47 ± 0.71) times / week, the number of enuresis in the observation group was significantly less than that in the control group (P <0.05). After 3 months of follow-up, 10 children in the observation group relapsed with a relapse rate of 11.90% In the control group, 23 cases of children relapsed with the recurrence rate of 27.38%. The recurrence rate of observation group was significantly lower than that of control group, the difference was statistically significant (P <0.05). Conclusion: The combination of desmopressin and Wenshen Jianpi can effectively reduce the number of enuresis in children with enuresis. It has good clinical curative effect and low relapse rate after stopping medicine, which has a good clinical value.