纯单黄酮甙对~(131)碘—胰岛素与脂肪细胞结合的影响

• 作 者: 于志清 简锦溢 黄瑞衡
• 机 构: 广西医学院内科内分泌组,广西医学院内科内分泌组,广西医学院内科内分泌组,
• 出 处: 广西医学院学报
• 发表日期: 1980年01期
• 关键词: 黄酮甙 番石榴叶 脂肪细胞 降糖作用 四氧嘧啶 成年型糖尿病 靶细胞 提取物 受体蛋白 药对

Cuatrecasas 及 Freychet 等证明在胰岛素的靶细胞—肝细胞与脂肪细胞膜上都存在着专一识别胰岛素的受体蛋白。几年来我们用番石榴叶治疗成年型糖尿病人,发现该药对成年高胰岛素水平或正常胰岛素水平的糖尿病人疗效较好,而且番石榴叶的提取物一黄酮甙对实验性四氧嘧啶性糖尿病大白鼠及正常大白鼠均有降糖作用,因此我们推想番石榴降糖作用原理不象是直接激发胰岛素B—细胞的释放作用。

Cuatrecasas and Freychet et al. demonstrated that there is a receptor protein that specifically recognizes insulin in target cells of insulin, both hepatocytes and adipocyte membranes. In the past few years we have used guava leaves to treat adults with type 2 diabetes. We have found that the drug has a good effect on adult people with high insulin levels or normal insulin levels, and that guava leaf extract, flavonoids, is an experimental type of alloxan-induced diabetes. Both rats and normal rats have hypoglycemic effects. Therefore, we hypothesize that the principle of guava hypoglycemic effect is not like the direct release of insulin B-cells.