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目的探讨原发性结直肠非霍奇金淋巴瘤的临床表现及内镜和病理特点。方法回顾性分析24例原发性结直肠非霍奇金淋巴瘤患者的临床资料。结果全组临床表现以腹痛、腹块、体重下降、发热、便血和大便习惯改变为主。多部位病变[涉及2个(包括2个)以上]6例(25．0%),其中3例由乙状结肠至升结肠呈跳跃样连续分布,1例病变为全结直肠跳跃样连续分布,1例涉及升结肠和直肠,1例涉及直肠和乙状结肠；单部位病变18例,以回盲部最多(44．4%,8例)。内镜下39．1%表现为溃疡型,43．5%为隆起型,17．4%为浸润型。11例(45．8%)病理分型为弥漫性大B细胞淋巴瘤,8例(33．3%)为肠道外周T细胞淋巴瘤,3例(12．5%)为黏膜相关淋巴组织边缘带B细胞淋巴瘤,2例(8．3%)未作分型。21例手术,其中根治性切除15例,局部切除1例,姑息切除4例,剖腹探查活检1例；16例(66．7%)术后加用CHOP(环磷酰胺、表阿霉素、长春新碱、泼尼松)或COP(环磷酰胺、长春新碱、泼尼松)方案化疗,放弃治疗3例。随访21例患者,5年生存率37．7%。结论原发性结直肠非霍奇金淋巴瘤临床表现无特异性；内镜以溃疡型和隆起型多见；病理分型以弥漫性大B细胞淋巴瘤和肠道外周T细胞淋巴瘤为主。手术加化疗的综合治疗是提高生存率的有效手段。
Objective To investigate the clinical features, endoscopic and pathological features of primary colorectal non-Hodgkin’s lymphoma. Methods The clinical data of 24 patients with primary colorectal non-Hodgkin’s lymphoma were retrospectively analyzed. Results The clinical manifestations of the whole group were mainly abdominal pain, abdominal mass, weight loss, fever, blood in the stool and stool habits. Multi-site lesions [involving 2 (including more than 2)] 6 cases (25.0%), of which 3 cases were continuously distributed from the sigmoid colon to the ascending colon was jumping, 1 case of lesions were all rectum-like continuous distribution, 1 Cases involved ascending colon and rectum, 1 case involved the rectum and sigmoid colon; single site lesions in 18 cases, the largest ileocecal area (44.4%, 8 cases). 39.1% endoscopic showed ulceration, 43.5% for the bulge, 17.4% for the infiltration. Eleven patients (45.8%) had diffuse large B-cell lymphoma, 8 (33.3%) had peripheral T-cell lymphoma and 3 (12.5%) mucosa-associated lymphoid tissue Marginal B-cell lymphoma, 2 cases (8.3%) did not type. Twenty-one patients underwent radical resection, including 15 cases of radical resection, 1 case of partial resection, 4 cases of palliative resection and 1 case of laparotomy. Sixteen patients (66.7%) were treated with CHOP (cyclophosphamide, epirubicin, Vincristine, prednisone) or COP (cyclophosphamide, vincristine, prednisone) regimen chemotherapy, to give up treatment in 3 cases. Follow-up 21 patients, 5-year survival rate of 37.7%. Conclusions The clinical manifestations of primary colorectal non-Hodgkin’s lymphoma are nonspecific. Endoscopy is more common in ulcers and bulge types. The pathological type is mainly diffuse large B-cell lymphoma and intestinal peripheral T-cell lymphoma . Comprehensive treatment of surgery and chemotherapy is an effective means to improve the survival rate.