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目的探讨宫颈癌术后应用调强适形放疗(IMRT)联合卡铂治疗的临床效果。方法选取2010年6月至2012年7月高州市人民医院确诊的宫颈癌术后患者86例,按联合化疗药物的不同分为卡铂组和顺铂组两组。比较两组患者的3年生存率及不良反应发生情况。结果卡铂组3年生存率为75.61%,略高于顺铂组的66.67%,差异未见统计学意义(P>0.05);卡铂组中等及以下胃肠道、肝肾及血液系统不良反应发生率依次为95.35%、93.02%、65.12%,均明显高于顺铂组,差异有统计学意义(P<0.05);卡铂组中等及以下脱发发生率为27.91%,明显低于顺铂组,差异有统计学意义(P<0.01)。结论宫颈癌术后应用调强适形放疗联合卡铂化疗的临床效果明显,同时放、化疗引起的不良反应程度较低,患者可耐受,值得临床推广应用。
Objective To investigate the clinical effect of IMRT combined with carboplatin after cervical cancer surgery. Methods Totally 86 patients with cervical cancer confirmed by Gaozhou Municipal People’s Hospital from June 2010 to July 2012 were divided into carboplatin group and cisplatin group according to the different chemotherapy drugs. Three-year survival rate and adverse reactions were compared between the two groups. Results The 3-year survival rate of carboplatin group was 75.61%, slightly higher than that of cisplatin group (66.67%), the difference was not statistically significant (P> 0.05); Carboplatin group of gastrointestinal tract, liver, kidney and blood system adverse reactions occurred The rates were 95.35%, 93.02% and 65.12%, respectively, which were significantly higher than those in cisplatin group (P <0.05). The incidence of moderate and lower alopecia in carboplatin group was 27.91%, which was significantly lower than that in cisplatin group There was statistical significance (P <0.01). Conclusions The application of IMRT combined with carboplatin after cervical cancer operation has obvious clinical effect. The side effects caused by radiotherapy and chemotherapy are lower and patients are tolerable, which is worthy of clinical application.