慢性阻塞性肺病与红细胞免疫相关性的探讨

• 作 者: 王恩举 张元和 潘立民 孙顺杰 蒋伟杰
• 机 构: 蚌埠铁路中心医院内科,蚌埠医学院微生物学教研室
• 出 处: 蚌埠医学院学报
• 发表日期: 1999年01期
• 关键词: 慢性阻塞性肺病 红细胞免疫 急性发作期 红细胞膜 免疫活性 肺疾病.阻塞性 补体致敏酵母菌 高碳酸血症 差异有显著性 荷瘤鼠

目的：探讨慢性阻塞性肺病（ＣＯＰＤ）急性发作期（Ａ组）和缓解期（Ｂ组）红细胞免疫功能的相关性。方法：用郭峰法检查ＣＯＰＤ的Ａ、Ｂ组红细胞Ｃ３ｂ受体花环率（ＲＢＣＣ３ｂＲＲ）、红细胞免疫复合物花环率（ＲＢＣＩＣＲＲ）和红细胞免疫粘附促进因子（ＲＦＥＲ）、红细胞免疫粘附抑制因子（ＲＦＩＲ）。结果：Ａ组ＲＢＣＣ３ｂＲＲ、ＲＦＥＲ均较Ｂ组降低（Ｐ＜０．０５～Ｐ＜０．０１），Ａ组ＲＢＣＩＣＲＲ、ＲＦＩＲ与Ｂ组间差异均无显著性（Ｐ＞０．０５）。结论：ＣＯＰＤ在急性发作期红细胞免疫功能显著降低；提高红细胞免疫功能，可能有助于急性发作期的缓解和好转。

Objective: To investigate the correlation between erythrocyte immune function in acute exacerbation (group A) and remission (group B) of chronic obstructive pulmonary disease (COPD). Methods: The levels of RBCC3bRR, RBCICRR, erythrocyte immune adherence (RFER), red blood cell immune adherence Inhibitor (RFIR). Results: The RBCC3bRR and RFER in group A were lower than those in group B (P <0.05 ~ P <0.01), but there was no significant difference between group A and group RBCICRR, RFIR and group B ). CONCLUSION: COPD has a markedly decreased erythrocyte immune function during acute exacerbation. Increasing erythrocyte immune function may contribute to the alleviation and improvement of acute exacerbation.