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Objective: To study the Bsm I single nucleotide polymorphism (SNP) of vitamin D receptor gene (VDRG) in low-risk Chinese Han population and its relationship to the susceptibility to prostate cancer (PCa). Methods: One hundred and three PCa patients and 106 normal controls from North China Han population were enrolled. Blood samples were obtained and genotyped for Bsm I SNP by denaturing high performance liquid chromatography (DHPLC) methods. Results: There was no significant difference in the distribution of genotype and allele between the PCa patients and the normal controls (P>0.05). The frequencies for the bb, Bb and BB genotypes in PCa patients and normal controls were 92.23%/94.34 %, 7.77 %/5.66 %, and 0/0, respectively. The frequencies for B and b allele were 3.88 % and 96.12 %, and 2.91 % and 97.09 %, respectively. Conclusion: There is no significant relationship between the VDRG polymorphism and PCa in North China Han population. The distribution of VDRG Bsm I SNP varies in different ethnic popul
Objective: To study the Bsm I single nucleotide polymorphism (SNP) of vitamin D receptor gene (VDRG) in low-risk Chinese Han population and its relationship to the susceptibility to prostate cancer (PCa). Methods: One hundred and three PCa patients and 106 normal controls from North China Han population were enrolled. Blood samples were obtained and genotyped for Bsm I SNP by denaturing high performance liquid chromatography (DHPLC) methods. Results: There was no significant difference in the distribution of genotype and allele between the PCa patients and the normal controls (P> 0.05). The frequencies for the bb, Bb and BB genotypes in PCa patients and normal controls were 92.23% / 94.34%, 7.77% / 5.66%, and 0/0, respectively. The frequencies for B and b allele were 3.88% and 96.12%, and 2.91% and 97.09%, respectively. Conclusion: There is no significant relationship between the VDRG polymorphism and PCa in North China Han population. The distribution of VDRG Bsm I SNP varies in dif ferent ethnic popul