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目的:探讨联合检测血清肿瘤标志物癌胚抗原(CEA)和糖类抗原19-9(CA19-9)在D2胃癌术后患者随访中的应用价值。方法:采集271例D2胃癌术后病人血清,利用免疫荧光分析法检测血清中CEA和CA19-9含量,并根据检验结果划分为CEA(-)/CA19-9(-)、CEA(+)/CA19-9(-)、CEA(-)/CA19-9(+)和CEA(+)/CA19-9(+)四个组。采用Kaplan-meier法进行生存率分析,利用Log-rank检验进行统计学差异性比较,χ2检验进行组间单因素分析。结果:两种肿瘤标志物CEA和CA19-9的联合检测时,两个同时为阳性组患者生存期远远低于单一阳性组;CEA(+)/CA19-9(-)组与CEA(-)/CA19-9(+)组比较,CEA(-)/CA19-9(+)组患者生存期要低于对照组,具有统计学差异(P<0.05)。结论:联合检测血清肿瘤标志物CEA和CA19-9在D2胃癌术后患者随访中,CA19-9阳性者提示更差的预后。
Objective: To investigate the value of combined detection of serum tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in the follow-up of postoperative patients with D2 gastric cancer. Methods: Serum samples of 271 patients with D2 gastric cancer were collected. The levels of CEA and CA19-9 in serum were detected by immunofluorescence analysis and divided into CEA (-) / CA19-9 (-), CEA (+) / CA19-9 (-), CEA (-) / CA19-9 (+) and CEA (+) / CA19-9 (+). Kaplan-Meier survival rate analysis, using Log-rank test for statistical differences, χ2 test for univariate analysis between groups. Results: When the two tumor markers CEA and CA19-9 were combined, the survival of two patients who were both positive and negative was much lower than that of the single positive patients. The survival rates of CEA (+) / CA19-9 (- ) Patients in the CEA (-) / CA19-9 (+) group were significantly lower than those in the control group (P <0.05). Conclusions: Combined detection of serum tumor markers CEA and CA19-9 in patients with D2 gastric cancer postoperative follow-up, CA19-9-positive patients showed a worse prognosis.