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目的 :研究络通喷雾剂的抗炎作用与皮肤急性毒性反应 ,以了解该制剂作用特点。方法 :采用致炎物角叉菜胶和二甲苯 ,分别造成大鼠足跖肿胀和皮肤毛细血管扩张等非特异性炎症模型 ,利用络通喷雾剂进行实验性治疗 ;将大剂量络通喷雾剂用于豚鼠脱毛皮肤区 ,观察有否急性毒性反应 ;结果 :络通喷雾剂对角叉菜胶导致大鼠足跖肿胀有明显抑制作用 ,同时显著抑制二甲苯滴于小鼠腹部皮肤引起的毛细血管通透性的增高 ;该制剂大剂量使用后 ,无一动物出现急性毒性反应。结论 :络通喷雾剂有较好的抗非特异性炎症作用 ,且该制剂的使用是安全的
Objective : To study the anti-inflammatory effect of Luotong Spray and the acute toxicity of skin to understand the characteristics of the preparation. METHODS: Carrageenan and xylene were used to induce non-specific inflammation models such as swelling of paws and expansion of skin capillaries in rats. The experimental treatment was carried out with Luotong spray; large dose of Luotong spray was used. In the skin area of guinea pig hair removal, to observe whether there is an acute toxicity reaction; Results: Luo Tong spray on carrageenan caused significant inhibition of paw swelling in rats, while significantly inhibiting the xylene drop in mice abdominal skin caused by capillaries Permeability increased; no acute toxicity was observed in any of the animals after high dose administration. Conclusion: Luotong spray has better anti-non-specific inflammatory effects, and the use of the preparation is safe