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A novel method of synthesis of nitro or trifluoromethyl substituted benzimidazolyl-phenoxyacetic acid O-acetylglucosyl saccharide esters by the reaction of O-acetylglucosyl bromide with substituted benzimidazolyl -phenoxyacetic acid at room temperature was developed. 4-dimethylaminopyridine (DMAP) was used as catalyst, triethylamine (Et_3N) was used as deacid reagent, three saccharide esters were synthesized in the system of DMAP/ Et_3N. The catalytic mechanism of DMAP/Et_3N was discussed. The results show that DMAP is an effective catalyst, the yields can reach 50%. The test indicates that the title compounds show better antiplantviral activity.
A novel method of synthesis of nitro or trifluoromethyl substituted benzimidazolyl-phenoxyacetic acid O-acetylglucosyl saccharide esters by the reaction of O-acetylglucosyl bromide with substituted benzimidazolyl-phenoxyacetic acid at room temperature was developed. 4-dimethylaminopyridine (DMAP) was used as catalyst, triethylamine (Et_3N) was used as a deacid reagent, three saccharide esters were synthesized in the system of DMAP / Et_3N. The catalytic mechanism of DMAP / Et_3N was discussed. The results show that DMAP is an effective catalyst, the yield can reach 50%. The test indicates that the title compounds show better antiplantviral activity.