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目的研究非酒精性脂肪肝应用多烯磷脂酰胆碱辅以二甲双胍治疗的临床疗效。方法 80例非酒精性脂肪肝患者随机分为治疗组及对照组各40例,治疗组给予多烯磷脂酰胆碱联合二甲双胍,对照组单用多烯磷脂酰胆碱,疗程结束后比照两组临床疗效及ALT、AST、G-GT、TC、TG的水平改变情况。结果治疗组总有效率为84%,显著高于对照组的52%。两组治疗前ALT、AST、C-GT无显著差异,治疗后较治疗前均下降显著,治疗组下降幅度好于参照组。治疗组T C及TG较治疗前显著下降,对照组无显著改善。两组均无明显不良反应发生。结论非酒精性脂肪肝应用多烯磷脂酰胆碱辅以二甲双胍疗效确切。
Objective To study the clinical efficacy of polyene phosphatidylcholine supplemented with metformin in nonalcoholic fatty liver. Methods A total of 80 patients with non-alcoholic fatty liver were randomly divided into treatment group (40 cases) and control group (40 cases). The treatment group received polyene phosphatidylcholine combined with metformin, while the control group received polyene phosphatidylcholine alone. Clinical efficacy and ALT, AST, G-GT, TC, TG levels change. Results The total effective rate was 84% in the treatment group, which was significantly higher than that in the control group (52%). There was no significant difference in ALT, AST and C-GT between the two groups before treatment, and there was a significant decrease after treatment in both groups. The reduction rate in the treatment group was better than that in the reference group. T C and TG in treatment group decreased significantly compared with those before treatment, but no significant improvement in control group. No significant adverse reactions occurred in both groups. Conclusion Non-alcoholic fatty liver polyplene phosphatidylcholine with metformin curative effect is exact.