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目的探讨低钾型周期性麻痹(hypokalemicperiodicparalysis.HOPP)的诱发因素、临床表现及诊治体会。方法回顾性分析96例HOPP患者的临床资料。结果发病前常有明显诱因,发病多在夜间睡眠中或凌晨清醒后。最早表现为四肢不同程度的迟缓性的肌无力,部分重度HOPP患者可并发心律失常及呼吸肌麻痹,急诊心电图检查发现所有病例均有典型T波改变。95例患者经静脉及口服补钾,配合安体舒通、硫酸镁治疗后症状完全缓解,1例重度患者死于休克和严重心率失常。结论对于HOPP,及早诊治是关键;而对于重度HOPP,心电监护、抗心率失常药物、抗休克治疗和呼吸机辅助呼吸是抢救成功的重要措施。
Objective To investigate the predisposing factors, clinical manifestations, diagnosis and treatment of hypokalemic periodaneparasis (HOPP). Methods The clinical data of 96 HOPP patients were retrospectively analyzed. Results Before the onset of obvious incentive, the incidence of sleep at night or more in the early morning after awake. The earliest manifestations of varying degrees of delayed limb weakness, some patients with severe HOPP may be complicated by arrhythmia and respiratory muscle paralysis, emergency ECG found in all cases have a typical T wave changes. 95 patients with intravenous and oral potassium, with spironolactone, magnesium sulfate symptoms completely relieved, 1 patient died of severe sepsis and severe heart rate disorders. Conclusions Early detection and treatment of HOPP is the key. Severe HOPP, ECG monitoring, anti-arrhythmic drugs, anti-shock therapy and ventilator-assisted breathing are important measures for successful rescue.