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为探讨多发性骨髓瘤（ＭＭ）患者细胞免疫功能和外周血肿瘤前体细胞的变化及其意义，应用间接免疫荧光法对２６例ＭＭ患者外周血Ｔ淋巴细胞亚群和携带浆细胞相关抗原（ＰＣＡＡ）——ＣＤ３８＋的淋巴细胞进行了检测。结果表明：①ＭＭ患者ＣＤ３＋（总Ｔ）细胞、ＣＤ４＋（ＴＨ）细胞、ＣＤ４＋／ＣＤ８＋比值下降（Ｐ＜０．０５），而ＣＤ８＋（ＴＳ／ＴＣ）细胞无明显变化。②ＭＭ患者外周血ＣＤ３８＋细胞明显增高，化疗后ＣＤ３８＋细胞数量明显下降（Ｐ＜０．０５）。结论：①ＭＭ患者体内存在细胞免疫功能紊乱。②ＭＭ患者外周血中存在肿瘤前体细胞，并且与疾病的临床分期和化疗有关。
To investigate the changes of cellular immune function and peripheral blood tumor precursor cells in patients with multiple myeloma (MM), indirect immunofluorescence was used to analyze the peripheral blood T lymphocyte subsets and plasma cell-associated antigens in 26 MM patients. PCAA)-CD38+ lymphocytes were tested. The results showed that the ratio of CD3+ (total T) cells, CD4+ (TH) cells, and CD4+/CD8+ decreased in 1MM patients (P<0.05), but there was no significant change in CD8+ (TS/TC) cells. CD38+ cells in peripheral blood of 2MM patients were significantly increased, and the number of CD38+ cells decreased significantly after chemotherapy (P<0.05). Conclusion: There are cellular immune disorders in 1 MM patients. The presence of tumor precursor cells in the peripheral blood of 2MM patients is associated with the clinical stage of the disease and chemotherapy.