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目的探讨血清半胱氨酸蛋白酶抑制剂C(Cystatin C)与乙型肝炎的关系。方法用颗粒增强透射免疫比浊法检测97例乙型肝炎患者及25例健康志愿者的血清Cystatin C水平,同时测其血清HBV-DNA(定量)、ALT、AST、TBIL、PT以及透明质酸(HA)、III型前胶原(PIIIP)、IV型胶原(CL-IV)、层粘连蛋白(LN)等。分析血清Cystatin C与临床类型及HBV-DNA、HBV-M、肝纤维化血清学指标间的关系。结果血清Cystatin C水平在不同临床类型的乙型肝炎间差异无统计学意义;Cystatin C与HBV-DNA(定量)、ALT、AST、TBIL、PT以及血清纤维化指标等不相关。结论血清Cystatin C与乙型肝炎的临床类型不相关。
Objective To investigate the relationship between serum cystatin C and hepatitis B virus. Methods Serum levels of Cystatin C in 97 patients with hepatitis B and 25 healthy volunteers were measured by particle-enhanced immunoturbidimetry. Serum HBV-DNA (quantitative), ALT, AST, TBIL, PT and hyaluronic acid (HA), type III procollagen (PIIIP), type IV collagen (CL-IV), laminin (LN) and the like. The relationship between serum Cystatin C and clinical types and serological markers of HBV-DNA, HBV-M and hepatic fibrosis was analyzed. Results Serum Cystatin C levels in different clinical types of hepatitis B were not significantly different; Cystatin C was not related to HBV-DNA (quantitative), ALT, AST, TBIL, PT and serum fibrosis indexes. Conclusion Serum Cystatin C is not related to the clinical type of hepatitis B.