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目的:为了寻求更好的预防输卵管妊娠后持续性异位妊娠临床治疗效果,分析和探讨在进行腹腔镜手术治疗过程中米非司酮联合甲氨蝶呤(MTX)的可行性和必要性。方法:选取120例于2009年1月~2013年12月期间在该院妇科住院治疗的输卵管妊娠患者作为研究对象,将其分为对照组(60例)和观察组(60例),其中对照组患者单纯采取腹腔镜手术治疗,观察组患者在采取腹腔镜手术治疗的同时应用米非司酮联合MTX治疗,对比和分析两组患者治疗效果和术后患者血中β-HCG的影响。结果:观察组患者的临床治疗效果和对照组患者比较差异具有统计学意义(P<0.05);而观察组患者术后2周血β-HCG降低的程度和对照组患者相比显著占优势,差异具有统计学意义(P<0.05)。结论:输卵管妊娠患者在进行腹腔镜手术治疗的过程中应用米非司酮联合MTX治疗,不仅可以提高患者的治疗效果,而且有利于降低血中β-HCG。
OBJECTIVE: To investigate the clinical effect of continuous ectopic pregnancy after tubal pregnancy, to investigate and discuss the feasibility and necessity of combining mifepristone and methotrexate (MTX) during laparoscopic surgery. Methods: One hundred and twenty cases of tubal pregnancy patients who were hospitalized in gynecology department from January 2009 to December 2013 were selected as study subjects, which were divided into control group (60 cases) and observation group (60 cases) Patients in the observation group were treated with laparoscopic surgery alone. Patients in the observation group were treated with mifepristone combined with MTX. Laparoscopic surgery combined with MTX was used to compare and analyze the therapeutic effect and β-HCG levels in the two groups. Results: The clinical treatment effect in the observation group was statistically significant compared with that in the control group (P <0.05); while in the observation group, the level of serum β-HCG decreased significantly 2 weeks after operation compared with the control group, The difference was statistically significant (P <0.05). Conclusion: The treatment of tubal pregnancy in patients undergoing laparoscopic surgery with mifepristone combined with MTX treatment, not only can improve the therapeutic effect of patients, but also help to reduce blood β-HCG.