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目的:探讨郭氏六联疗法联合西医治疗急性胰腺炎的临床疗效及安全性。方法:选取在本院进行治疗的急性胰腺炎患者96例,分为观察组与对照组,对照组患者给予西医常规治疗,观察组给予郭氏六联法联合西医常规治疗,对比两组患者临床疗效、临床症状缓解时间、治疗前后实验室检查指标和病情严重程度评分,并观察两组患者与药物相关的不良反应发生情况。结果:观察组患者的临床总有效率明显高于对照组,不良反应发生率明显低于对照组,且排气恢复时间、腹痛消失时间、腹胀消失时间及住院时间均明显短于对照组(P<0.05);与治疗前对比,两组患者的血淀粉酶、白细胞总数、C反应蛋白、乳酸脱氢酶、急性生理和慢性健康估测Ⅱ(APCHE-Ⅱ)评分、改良Marshall评分和改良CT严重指数(MCTSI)均明显改善,且观察组患者改善更显著(P<0.05)。结论:郭氏六联疗法联合西医治疗急性胰腺炎临床疗效显著,能显著缩短临床症状缓解时间,降低不良反应发生率,值得临床推广应用。
Objective: To investigate the clinical efficacy and safety of Guo six combined with western medicine in the treatment of acute pancreatitis. Methods: Ninety-six patients with acute pancreatitis treated in our hospital were divided into observation group and control group. Patients in control group were treated with routine western medicine. Observation group was treated with Guo six-combined method and western medicine routine therapy. Efficacy, clinical symptom relief time, laboratory tests before and after treatment indicators and severity of illness score, and observed two groups of patients with drug-related adverse reactions. Results: The total clinical effective rate in observation group was significantly higher than that in control group, the incidence of adverse reactions was significantly lower than that in control group, and the recovery time of exhaust gas, disappearance of abdominal pain, disappearance of abdominal distention and hospitalization time were significantly shorter than those in control group (P <0.05). Compared with those before treatment, the blood amylase, leukocyte count, C-reactive protein, lactate dehydrogenase, acute physiology and chronic health assessment Ⅱ (APCHE-Ⅱ) score, modified Marshall score and modified CT Severe index (MCTSI) were significantly improved, and the observation group patients improved more significantly (P <0.05). Conclusion: Guoxiu six combined with Western medicine treatment of acute pancreatitis significant clinical effect, can significantly shorten the time to alleviate clinical symptoms and reduce the incidence of adverse reactions, deserved clinical application.