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目的为建立稳定可靠的视神经损伤动物模型寻求解剖学依据。方法用红色乳胶灌注技术显示正常SD大鼠视网膜中央动脉的来源、分支、分布及其与视神经的关系,并采用体视显微镜摄片测量;明胶墨汁灌注技术显示距眼球后极2.0 mm或6.0 mm处横断视神经后视网膜的血供。结果视网膜中央动脉及其分支在视神经鞘内始终与视神经干伴行,视网膜中央动脉起始部到眼球后极的距离为(5.784±0.054)mm;距离眼球后极6.0 mm处鞘内视神经横断组大鼠视网膜单位面积血管数目高于其他部位横断组。结论在制备视神经损伤SD大鼠模型时,损伤视神经应在鞘内进行,损伤部位距眼球后极6.0 mm最佳。
Objective To establish an anatomical basis for establishing a stable and reliable animal model of optic nerve injury. Methods The origin, branching and distribution of the central retinal artery in normal SD rats were observed by red latex perfusion technique and their relationship with the optic nerve was measured by stereomicroscope. The gelatin ink perfusion technique showed a distance of 2.0 mm or 6.0 mm Transection of the retina behind the blood supply. Results The central retinal artery and its branches were always accompanied with optic nerve trunk in the sheath of the optic nerve. The distance from the origin of the central retinal artery to the posterior pole of the eye was (5.784 ± 0.054) mm. From the posterior pole 6.0 mm, Rat retina per unit area of blood vessels is higher than other parts of the transection group. Conclusion In the preparation of optic nerve injury SD rat model, the optic nerve damage should be carried out intrathecally, the damage from the posterior pole of the eye 6.0 mm best.