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原发性肝细胞肝癌(HCC)的预后远较其他癌症差,早期侵袭转移是重要因素之一,导致其5年生存率极低。在肿瘤侵袭进程中,必须成功地完成3个过程:黏附细胞外基质(ECM)的蛋白质,降解ECM生长,离开ECM转移到别处。整合素是肿瘤细胞实现细胞-基质黏附的重要受体,在肿瘤基因学研究中已证实不同特定的整合素受体与多种癌症发病及侵袭转移有关。国外曾有文献认为在众多的层黏连蛋白(LN)受体中与肝癌的侵袭与转移、预后密切相关的整合
The prognosis of primary hepatocellular carcinoma (HCC) is far worse than that of other cancers. Early invasion and metastasis are one of the important factors, resulting in a very low 5-year survival rate. In the course of tumor invasion, three processes must be successfully accomplished: adhesion of extracellular matrix (ECM) proteins, degradation of ECM growth, exit of ECM for metastasis elsewhere. Integrin is an important receptor for tumor cells to achieve cell-matrix adhesion. It has been demonstrated in tumor genetics studies that different specific integrin receptors are involved in the pathogenesis and invasion and metastasis of various cancers. There have been foreign literature that in a large number of laminin (LN) receptor invasion and metastasis of liver cancer, the prognosis is closely related to the integration