论文部分内容阅读
目的:了解慢性HBV与非活动性HBsAg携带者肝组织病理学特点与年龄、HBV载量及临床的关系。方法:对符合慢性HBV携带者(69例)与非活动性HBsAg携带者(77例)诊断标准的146例行肝穿刺活组织学检查,判断肝组织炎症活动(G)、肝纤维化(S)分级、分期。结果:146例中>G0～检测值慢性乙肝患者扩大抗病毒治疗范围,防止肝脏不良事件(肝硬化、肝癌)发生。
OBJECTIVE: To investigate the relationship between pathological features and age, HBV load and clinical features in chronic HBV and non-active HBsAg carriers. Methods: A total of 146 patients with chronic HBV carriers (n = 69) and non-active carriers of HBsAg (n = 77) were examined by biopsies of liver biopsies to determine the inflammatory activity (G), hepatic fibrosis ) Classification, staging. Results: In 146 cases, there were 8 cases of G0 ~ G1, G1 78 cases, G2 G2 cases and G3 7 cases, which were 5.5%, 53.4%, 36.3% and 4.8% S2 5 cases, S3 2 cases, respectively 76.7%, 18.5%, 3.4% and 1.4%. G, S grade, stage severity and age was positively correlated, with statistical significance. Pathological changes of liver tissue in chronic HBV carriers have nothing to do with serum HBVDNA load. There was no significant difference in pathological changes of liver between chronic HBV and non-active HBsAg carriers. Conclusion: The liver tissue of chronic HBV carriers and non-active HBsAg carriers have different degrees of damage, the severity is positively correlated with age, and there is no fixed relationship with HBV load. It is recommended to quantify HBVDNA> detection of chronic hepatitis B patients to expand the scope of antiviral treatment to prevent the occurrence of adverse liver events (cirrhosis, liver cancer).