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浸泡凝血酶的明胶海绵作为止血剂已在神经外科应用了多年,但它对脑局部作用还不十分清楚。实验研究显示:将凝血酶立体定向注入大鼠基底节,术后24小时产生脑水肿。本实验研究了浸泡凝血酶的明胶海绵(浓度与应用于人的相似)对大鼠脑的影响。 实验选用250至300克的成年雄性SD大鼠,经气管插管,呼吸机控制呼吸,异氟醚麻醉。动物以俯卧位头架固定,无菌条件下手术。动物分为两组:第一组,浸泡溶剂或凝血酶(100U/cm~3)的明胶海绵被置于大鼠
Gelatin sponge soaked in thrombin as a hemostatic agent has been used in neurosurgery for many years, but its role in the brain is not yet fully understood. Experimental studies have shown that stereotactic injection of thrombin into rat basal ganglia produces cerebral edema 24 hours after surgery. This experiment investigated the effect of a thrombin-soaked gelatin sponge (concentration similar to that applied to humans) on rat brains. The experiment used 250 to 300 grams of adult male SD rats, tracheal intubation, breathing machine control breathing, isoflurane anesthesia. The animals were fixed in the prone position with a prosthesis under sterile conditions. The animals were divided into two groups: Group 1, gelatin sponges soaked in solvent or thrombin (100 U / cm ~ 3) were placed in rats