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目的:探讨尿路上皮分化特异糖蛋白(UPⅢ)的表达与腺性膀胱炎发病机制的相关性及临床意义。方法:用免疫组织化学方法研究UPⅢ在92例腺性膀胱炎、24例正常膀胱和16例膀胱移行细胞癌的表达情况。结果:腺性膀胱炎的UPⅢ表达位于腺上皮全层,膀胱移行细胞癌的UPⅢ表达主要在乳头的外周和囊腔。UPⅢ在腺性膀胱炎组的阳性表达率为63.0%(58/92),正常对照组为100.0%(24/24),两组间有显著性差异(P=0.0004)。膀胱癌组为75%(12/16),两组间无显著性差异(P=0.355)。腺性膀胱炎的UPⅢ表达阴性者34例,术后85.3%(29例)有症状,仅14.7%(5例)无不适症状。结论:UPⅢ大部分来源于移行(尿路)上皮,基本上支持上皮组织转化学说。UPⅢ阴性与腺性膀胱炎术后症状复发有关。
Objective: To investigate the correlation between the expression of urinary epithelial differentiation-specific glycoprotein (UPIII) and the pathogenesis of cystitis glandularis and its clinical significance. Methods: The expression of UPⅢ in 92 cases of cystitis glandularis, 24 cases of normal bladder and 16 cases of bladder transitional cell carcinoma were studied by immunohistochemistry. Results: The expression of UPⅢ in cystitis glandularis was located in the whole layer of glandular epithelium. The expression of UPⅢ in bladder transitional cell carcinoma was mainly in the periphery of the nipple and in the cyst. The positive expression rate of UPⅢin glandular cystitis group was 63.0% (58/92) and that in normal control group was 100.0% (24/24). There was a significant difference between the two groups (P = 0.0004). The bladder cancer group was 75% (12/16), no significant difference between the two groups (P = 0.355). In 34 patients with negative cystitis glandularis infection, 85.3% (29 cases) had symptoms and only 14.7% (5 cases) had no symptoms. CONCLUSIONS: Most of UPIII originates from the transitional (urinary) epithelium and basically supports epithelial tissue transformation. UP Ⅲ negative and glandular cystitis recurrence of symptoms related.