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目的评价HFL方案配合金龙胶囊治疗晚期胃癌的客观疗效及不良反应。方法56例晚期胃癌病人随机分成两组,金龙组采用HFL化疗方案联合金龙胶囊,对照组仅采用HFL方案,用法:HCPT10～15mgd1-4静点,5-FU500mgd1-3静点,CF100mgd1-3静点4每3周为1周期,化疗2周期评价,金龙组加用口服金龙胶囊4粒日3次,连用6周。结果对照组有效率为48.3%,PD率31.0%,金龙组有效率为59.3%,PD率7.4%,金龙组有效率高于对照组,金龙组PD率低于对照组,但两组比较无显著性差异。金龙组一般症状改善好于对照组,但无统计学意义。化疗不良反应主要为口腔炎,腹泻,骨髓抑制,金龙组低于对照组,有统计学意义。结论金龙胶囊联合HFL方案治疗晚期胃癌,不良反应轻,值得进一步临床研究。
Objective To evaluate the objective efficacy and adverse reactions of HFL combined with Jinlong Capsule in the treatment of advanced gastric cancer. Methods 56 cases of advanced gastric cancer patients were randomly divided into two groups, Jinlong group using HFL chemotherapy combined with Jinlong capsule, the control group only HFL program, usage: HCPT10 ~ 15mgd1-4 static point, 5-FU500mgd1-3 static point, CF100mgd1-3 static Point 4 every 3 weeks for 1 cycle, 2 cycles of chemotherapy evaluation, Jinlong group plus oral Jinlong capsule 4 capsules 3 times a day, once every 6 weeks. Results The effective rate of the control group was 48.3%, the PD rate was 31.0%, the effective rate of Jinlong group was 59.3% and the PD rate was 7.4%. The effective rate of Jinlong group was higher than that of the control group. The PD rate of Jinlong group was lower than that of the control group Significant difference. Jinlong group general symptoms better than the control group, but no statistically significant. Adverse reactions to chemotherapy mainly stomatitis, diarrhea, bone marrow suppression, Jinlong group was lower than the control group, with statistical significance. Conclusion Jinlong Capsule combined with HFL regimen in the treatment of advanced gastric cancer has mild side effects and deserves further clinical study.