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目的研究黄体酮-平阳霉素乳剂在子宫肌瘤介入治疗中的临床疗效及副反应。方法随机将110例子宫肌瘤患者分为聚乙烯醇微粒和黄体酮-平阳霉素乳剂栓塞2组。采用Seldinger技术,经皮穿刺行双侧子宫动脉插管,注入黄体酮-平阳霉素乳剂或聚乙烯醇微粒阻断子宫肌瘤血供。治疗前后均用B超测量子宫肌瘤体积,并观察术后各种反应和月经量变化。结果2组患者月经量恢复正常和明显减少,总有效率为95.49%;术后3个月和6个月肌瘤体积较治疗前缩小45.81%和51.80%。与治疗前比较有显著差异(P<0.01)。2组在月经量改变和子宫肌瘤体积变化上比较无显著差异。术后发热及缺血性盆腔疼痛为2组的主要副反应,无严重并发症。结论使用黄体酮-平阳霉素乳剂栓塞子宫动脉治疗子宫肌瘤,创伤小、疗效好、副作用小。黄体酮-平阳霉素乳剂是一种经济有效的新型栓塞剂。
Objective To study the clinical efficacy and side effects of progesterone-pingyangmycin emulsion in the interventional treatment of uterine fibroids. Methods 110 cases of uterine fibroids were randomly divided into polyvinyl alcohol particles and progesterone - pingyangmycin emulsion embolization two groups. Using Seldinger technique, percutaneous puncture of bilateral uterine artery intubation, injection of progesterone - pingyangmycin emulsion or polyvinyl alcohol particles block uterine fibroids blood supply. Before and after treatment with B ultrasound measurement of uterine fibroids volume, and observed postoperative changes in various reactions and menstrual flow. Results The menstrual flow in both groups returned to normal and decreased significantly, with a total effective rate of 95.49%. The volume of myoma at 3 months and 6 months after operation was reduced by 45.81% and 51.80% respectively. Compared with before treatment, there was a significant difference (P <0.01). There was no significant difference between the two groups in the change of menstrual volume and the change of the volume of uterine fibroids. Postoperative fever and ischemic pelvic pain were the main side effects of the two groups, without serious complications. Conclusion Progesterone - pingyangmycin emulsion embolization uterine artery embolization of uterine fibroids, trauma, good curative effect, side effects. Progesterone - Pingyangmycin emulsion is a new type of cost-effective embolic agent.