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本文研究了糖尿病人中HDL糖化过程的特点和血糖恢复正常后糖化HDL消失的时间,发现糖尿病人的糖化HDL水平较对照者高4倍;糖化HDL水平和采血前第4天的糖浓度呈显著正相关;糖化HDL中载脂蛋白(Apo)A-Ⅰ占80％以上,高度纯化的Apo A-Ⅰ经与不同浓度的葡萄糖在37℃下共同保温后,其糖化程度与保温时间及葡萄糖浓度成正比,Ⅱ型糖尿病人在静脉滴注胰岛素使血糖水平恢复正常后,血浆甘油三酯和总胆固醇迅速下降,HDL中甘油三酯显著减少而胆固醇增高。糖化HDL在血浆中的半衰期为78小时,略短于Apo A-Ⅰ,有可能后者的非酶糖化使其分解代谢加速。
In this paper, the characteristics of HDL saccharification in diabetic patients and the disappearance of glycosylated HDL after blood glucose returned to normal were observed. The levels of glycated HDL in diabetic patients were found to be 4 times higher than those in controls. The levels of glycated HDL and the 4th day before blood sampling were significantly higher (P <0.05) .Apo A-Ⅰ accounted for more than 80% in HDL. The highly purified Apo A-Ⅰ was incubated with different concentrations of glucose at 37 ℃, the degree of saccharification and incubation time and glucose concentration As a direct result, plasma triglycerides and total cholesterol rapidly decline in patients with type 2 diabetes after intravenous infusion of insulin to normalize their blood glucose levels. Triglyceride levels are significantly reduced and cholesterol levels are elevated in HDL. The half-life of glycated HDL in plasma is 78 hours, slightly shorter than that of Apo A-I, and it is possible that the latter non-enzymatic glycation accelerates catabolism.