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肝在维持体内铁平衡中起重要作用,主要是作为铁的储存器官以及转铁蛋白的合成场所。正常情况下,储存铁主要位于肝细胞,小部分位于枯否氏细胞。肝细胞合成转铁蛋白,并分泌进入血浆。转铁蛋白将从小肠吸收的铁送至肝脏及网状内皮系统内储存,或送至骨髓,肌肉和肝以便应用。肝中铁储量的变化决定于以无毒性蛋白结合型储存的铁量与肝内外合成血红素所需铁量之间的平衡。这种平衡由肝内进行的一系列复杂过程调节。体内铁的分布与吸收正常成年人体内铁总量为4～5 g,其中60～65%位于循环红血球的血色素内。约10%
Liver plays an important role in maintaining iron balance in the body, primarily as a storage site for iron and as a synthesis site for transferrin. Under normal circumstances, the storage of iron is mainly located in liver cells, a small part of Kupffer cells. Liver cells synthesize transferrin and are secreted into the plasma. Transferrin transports the iron absorbed from the small intestine to the liver and reticuloendothelial system for storage, or to the bone marrow, muscle and liver for use. The change in liver iron reserves depends on the balance between the amount of iron stored with non-toxic protein-bound stores and the amount of iron needed to synthesize heme within and outside the liver. This balance is regulated by a series of complex processes in the liver. Distribution and absorption of iron in the body Normal adults, the total body iron is 4 ~ 5 g, of which 60 ~ 65% located within the hemoglobin circulating red blood cells. About 10%