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目的:针对性地开展出生缺陷干预,为基层制定有效干预措施和降低出生缺陷提供依据。方法:对3241例孕妇分别进行乙型肝炎病毒、微量元素钙、铜、铁、锌等含量及弓形虫和风疹病毒检查,用三维彩色多普勒超声诊断仪对胎儿进行产前诊断。结果:筛查出乙肝病毒携带者和大、小三阳共188例,占6.31%,孕妇血清中微量元素未达标准为237～681例,占7.31%～21.01%,弓形虫和风疹病毒感染分别为0.40%和0.34%,三维彩超查出胎儿头颅、肢体和腹部畸形14例,占0.60%。结论:针对性的开展出生缺陷筛查和孕期干预,可预防和降低出生缺陷的发生。
OBJECTIVE: To carry out targeted birth defect interventions and provide evidences for establishing effective interventions and reducing birth defects at the grassroots level. Methods: The levels of hepatitis B virus, trace elements calcium, copper, iron and zinc, and toxoplasma gondii and rubella virus were examined in 3241 pregnant women respectively. Prenatal diagnosis was performed on the fetus with a three-dimensional color Doppler ultrasound diagnostic apparatus. Results: 188 cases of hepatitis B virus carriers and large and small Sanyang were screened out, accounting for 6.31%. The underitable serum levels of trace elements in pregnant women ranged from 237 to 681 (7.31% to 21.01%). Toxoplasma gondii and rubella virus infections 0.40% and 0.34% respectively. Fetal head, limbs and abdomen deformities were found in 14 cases (0.60%) by three-dimensional ultrasonography. Conclusion: Targeted screening for birth defects and pregnancy intervention can prevent and reduce the incidence of birth defects.