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实验研究了从溶血性链球菌提取的多糖制备物OK432对受照小鼠的辐射防护作用.OK432为溶血性链球菌减毒株冻干制备物,其含量用KE表示,即1KE相当于0.1mg干细胞.小鼠受照剂量率为33cGy/min,OK432腹腔注射.8.5Gy剂量在30天内使所有小鼠致死,受照后立即注射OK432 12.5,25,50KE/kg,存活率增高,并呈剂量依赖趋势.50KE/kg为最大耐受剂量.对照组小鼠LD_(50)为7.55Gy,而单次注射OK432小鼠
The radiation protection effect of OK432, a polysaccharide preparation extracted from Streptococcus mutans, on irradiated mice was experimentally studied. OK432 is a lyophilized preparation of an attenuated strain of hemolytic streptococcus, the content of which is expressed by KE, ie 1 KE equivalent to 0.1 mg. Stem cells. Mice were irradiated at a dose rate of 33 cGy/min. OK432 administered intraperitoneally with a dose of 8.5 Gy. All mice were killed within 30 days. Immediately after exposure, OK432 was administered at 12.5, 25, and 50 KE/kg. The survival rate was increased. Dependent on the trend, 50 KE/kg was the maximum tolerated dose. The mice in the control group had LD_(50) of 7.55 Gy, and a single injection of OK432 mice.