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目的了解男性心力衰竭患者性激素水平与心力衰竭之间的关系。方法临床诊断为慢性心力衰竭患者共108例。年龄65～89(73.4±8.6)岁,超声心动图检查左室射血分数(LVEF)≤0.45。同期观察健康老年人120例作为对照组。结果心衰患者睾酮、FT、雌二醇明显降低(P<0.05)。LH、FH差异无统计学意义,SHBG水平显著增加(P<0.05)。FT水平与左室射血分数呈正相关。雄激素水平明显降低与心衰程度呈负相关。结论对于老年男性心衰患者,补充适量的雄激素,有可能改善心功能,从而改善患者的症状和预后。
Objective To understand the relationship between sex hormone levels and heart failure in male patients with heart failure. Methods Clinical diagnosis of chronic heart failure in a total of 108 patients. Aged 65-89 (73.4 ± 8.6) years old. Echocardiography left ventricular ejection fraction (LVEF) ≤0.45. The same period observed 120 healthy elderly as a control group. Results In patients with heart failure, testosterone, FT and estradiol were significantly decreased (P <0.05). There was no significant difference between LH and FH, SHBG level increased significantly (P <0.05). FT level and left ventricular ejection fraction was positively correlated. Significantly decreased androgen levels and heart failure was negatively correlated. CONCLUSIONS: In elderly men with heart failure, the addition of adequate amounts of androgens may improve cardiac function and thus improve the patient’s symptoms and prognosis.