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目的探讨磷酸肌酸钠治疗扩张型心肌病心力衰竭的临床疗效。方法扩张型心肌病心力衰竭患者48例,随机分为对照组24例和治疗组24例。对照组给予洋地黄制剂、利尿剂、硝酸酯类药物、ACEI、ARB或β受体阻滞剂治疗;治疗组在此基础上加用磷酸肌酸钠2.0g,静脉滴注,2次/d,疗程14d。观察治疗前后患者心率(HR)、心胸比、射血分数(LVEF)、每博量(sv)、每分钟排血量(CO)、心脏指数(CI)及左室舒张末期容量指数(LVEDVI)和收缩末期容量指数(LVESVI)。结果48例患者治疗后有45例心功能有显著改善(均P<0.05)。治疗组与对照组比较,LVEF、SV、CO有统计学差异(P<0.05)。结论磷酸肌酸钠可辅助治疗扩张型心肌病心力衰竭,改善心功能,特别是左室收缩功能,且安全可靠。
Objective To investigate the clinical efficacy of sodium creatine phosphate in the treatment of dilated cardiomyopathy with heart failure. Methods 48 cases of dilated cardiomyopathy patients with heart failure, were randomly divided into control group 24 cases and treatment group 24 cases. The control group was treated with digitalis, diuretics, nitrates, ACEI, ARB or β-blocker. On the basis of this, the treatment group was treated with 2.0g of sodium creatine phosphate intravenously, twice daily , Treatment 14d. The heart rate (HR), cardiothoracic ratio, LVEF, sv, CO, cardiac index (CI) and left ventricular end-diastolic volume index (LVEDVI) were observed before and after treatment. And end-systolic volume index (LVESVI). Results Forty-eight patients had significant improvement in cardiac function after treatment (all P <0.05). Compared with the control group, LVEF, SV and CO in the treatment group were significantly different (P <0.05). Conclusion Sodium creatine phosphate can assist in the treatment of dilated cardiomyopathy heart failure, improve cardiac function, especially left ventricular systolic function, and is safe and reliable.