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目的:探讨晚发型重症肌无力(MG)的手术疗效及手术适应证。方法:回顾性研究21例晚发型MG患者的手术疗效,并与早发型MG比较,分析影响疗效的可能因素。结果:早发型MG的手术疗效好于晚发型MG(82.9%vs 52.4%,P<0.05);晚发型MG的手术疗效低龄(50~60岁)组优于高龄(>60岁)组,术前病程短(<10个月)者优于病程长(>10个月)者,病理为胸腺增生者优于胸腺萎缩者。结论:手术对晚发型MG者疗效虽较早发型MG差,但仍是可供选择的一种重要方式,掌握相应的手术适应证有助于提高手术疗效。
Objective: To investigate the surgical efficacy and surgical indications of late-onset myasthenia gravis (MG). Methods: The clinical effects of 21 patients with late-onset MG were retrospectively studied and compared with those of early-onset MG. The possible factors influencing the efficacy were analyzed. Results: The effect of early-onset MG was better than that of late-onset MG (82.9% vs 52.4%, P <0.05). The late-onset MG was superior to the older group (> 60 years) Short duration of disease (<10 months) were better than duration (> 10 months), the pathology of thymus hyperplasia than thymus atrophy. Conclusion: Although the effect of surgery on late-onset MG is worse than that of early-onset MG, it is still an important way to choose. Obtaining the indications of operation can help to improve the curative effect.