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近年来对于脾虚证动物模型的研究,正从苦寒泻下、饮食偏嗜、饥饿等单一造模因素向多因素造模方向发展,运用多因素造模更加符合中医理论。中医学认为“苦寒伤胃”,即指过用苦寒之品会损伤脾胃、《难经·四十九难》有:“饮食劳倦则伤脾”,现代流行病学调查也说明劳倦和饥饱失常是脾虚证的重要致病因素。据此,本实验采用大黄苦寒伤胃,疲劳、饮食失节多因素致脾虚造模方法,既解决了造模因素单一的问题,又较符合中医病因学理论,取得了造模后各项结果,并经临床部分脾虚证患者取样检测,得到基本一致的结果。
In recent years, research on animal models of spleen deficiency syndrome has been progressing from the single cold modeling, eating preference, and hunger to a multi-factor model. Using multi-factorial modeling is more consistent with traditional Chinese medicine theory. Chinese medicine believes that “bitter cold hurts the stomach,” meaning that products that use bitter cold can damage the spleen and stomach. “Difficulties in the Nineteen Nine Difficulties” are: “Diet is tired and injure the spleen,” and modern epidemiological surveys also indicate fatigue and hunger. Abnormality is an important pathogenic factor of spleen deficiency syndrome. Based on this, the experimental model of spleen deficiency induced by Rhubarb’s bitter cold, injury to the stomach, fatigue, and eating disorder resulted in a solution to the problem of monotonous factors in modeling and to the theory of etiology of traditional Chinese medicine, and achieved various results after modeling. Sampling and testing were performed on patients with spleen deficiency syndrome in the clinical department, and basically consistent results were obtained.