父母亲生育年龄等围孕期因素与儿童孤独症谱系障碍的关联性

• 作 者: 毛燕燕 胡宏 陈东燕 杜亚松 房宇航 王尚明 李敏 周维谨
• 机 构: 上海市生物医药技术研究院，国家卫生健康委员会计划生育药具重点实验室，上海 200237;上海市静安区静安寺街道社区卫生服务中心，上海 200040;上海市静安区彭浦新村街道社区卫生服务中心，上海 20
• 出 处: 中华生殖与避孕杂志
• 发表日期: 2022年4期
• 关键词: Risk factor Paternal age Maternal age Autism spectrum disorder

目的:分析父母亲生育年龄等围孕期因素与儿童孤独症谱系障碍（autism spectrum disorder，ASD）的关联性。方法:本研究采用病例对照研究，选取2018年6月至2019年2月期间就诊于上海市精神卫生中心且被诊断为ASD 的2~6岁儿童（病例组，n n=104），对照为同期就诊于上海静安寺街道/上海彭浦新村街道社区卫生服务中心的2~6岁非ASD儿童（对照组，n n=149）。采用多因素logistic回归模型分析父母亲年龄等围孕期因素与儿童ASD间的关联性。n 结果:多因素logistic回归分析显示，父亲生育年龄≥35岁（n OR=3.65，95% n CI=1.19~11.15，n P=0.023）、父母亲孕前或孕期患病（n OR=3.34，95% n CI=1.41~7.94，n P=0.006）以及儿童性别为男孩（n OR=5.84，95% n CI=2.98~11.44，n P<0.001）与儿童ASD患病风险增加相关。父亲生育年龄≥35岁的男童比父亲生育年龄<35 岁的男童、父亲生育年龄≥35岁的女童患ASD的风险高，差异具有统计学意义（n P=0.005，n P=0.006）。n 结论:父亲生育年龄与儿童ASD患病风险相关，且男童中的作用可能更明显，但需要前瞻性、大样本流行病学研究进行验证。“,”Objective:To examine the association between parental characteristics and risk of autism spectrum disorder (ASD) in children.Methods:In this case-control study, the cases were defined as children who were diagnosed with ASD and were recruited from June 2018 to February 2019 in Shanghai Mental Center (n n=104). The controls were defined as children who did not have ASD and were recruited in the two community health centers in Jing-an District of Shanghai during the same period (n n=149). All children recruited in this study were 2-6 years old. A multivariate logistic regression model was used to examine the association between parental characteristics and the risk of ASD in offspring, and further to estimate the interaction coefficient.n Results:According to multivariate regression analysis, the association between maternal age, previous pregnancy complication and the risk of ASD in children appeared to be not statistically significant. After adjusted, advanced paternal age (≥35 years old)(n OR=3.65, 95% n CI=1.19-11.15, n P=0.023), parental disease before or during pregnancy (n OR=3.34, 95% n CI=1.41-7.94, n P=0.006) and gender of child (male) (n OR=5.84, 95% n CI=2.98-11.44, n P<0.001) were associated with increased risk of ASD. The results also showed that the boys whose father was 35 years old or more had a higher risk of ASD than the boys whose fahter was less 35 years old and the girls whose father was 35 years old or more (n P=0.005, n P=0.006).n Conclusion:Advanced paternal age was associated with increased risk of ASD in offspring and this effect may be more pronounced in boys.