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Objective:To observe the clinical efficacy of integrative medical therapy in treating post-craniocerebral traumatic mental disorder(PCT-MD).Methods:Sixty patients with confirmed diagnosis of PCT-MD were randomly assigned to the treated group and the control group equally.All were treated by conventional comprehensive West medicine.but to patients in the treated therapeutic course for both groups was 20 days.Changes in mental symptoms were observed and recorded on the 10th and 20th day and clinical efficacy as well as cranial CT image was estimated after termination of the treatment.Results:The clinical effective rate in the treated group and the control group was 96.67%and 83.30%respectively.Comparison between them showed significant difference(P＜0.05).Significant differences were also shown in the comparisons between the two groups in improving mental symptoms,either on the 10th or on the 20th day (P＜0.05 and P＜0.01 respectively),and in post-treatment cranial CT image(P＜0.05).Conclusion:Better efficacy could be obtained by integrative medical therapy in treating PCT-MD.