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患者男,27岁,头昏乏力,脾肋下1.5cm,WBC22,400,中幼粒1％,晚幼粒6％。骨髓极度增生,诊断慢粒。经COPA方案及马利兰治疗缓解22个月后急变,胸骨压痛,肝脾明显肿大,Hb6.8g,WBC25,600,原、早幼粒20％,嗜碱中幼粒24％,嗜碱晚幼粒13％,嗜碱分叶核23％,血小板4.8万。骨髓原、早幼粒22.5％,嗜碱中幼粒25％,嗜碱晚幼粒13％,嗜碱分叶核19％,POX(-),经COPA等治疗病情恶
Male, 27 years old, dizzy and fatigued, spleen rib 1.5cm, WBC22,400, 1% in juvenile, late juvenile 6%. Bone marrow hyperplasia, diagnosis of CML. The COPA program and Maryland treatment of 22 months after the relief of acute change, sternal tenderness, liver and spleen were significantly enlarged, Hb6.8g, WBC25,600, progenitor, promyelocytic 20%, basophils in 24%, basophils Granules 13%, basophilic leaf core 23%, 48000 platelets. 22.5% promyelocytic, 25% basophils, 13% basophils, 19% basophils, POX (-), COPA, etc.