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目的:探究维持性血液透析（maintenance hemodialysis，MHD）患者腹主动脉钙化与血清细胞分裂周期蛋白42（cell division cycle 42，CDC-42）水平的相关性，并探究两者的影响因素。方法:采用横断面研究方法，在青岛市市立医院血液净化中心选取2019年10月至2021年3月行MHD治疗至少6个月的患者112例。收集所有患者临床数据，应用腹部侧位X线平片计算其腹主动脉钙化积分（abdominal aortic calcification score，ACCs）。根据AACs分为无和轻度钙化组50例（0≤AACs<5分）、中重度钙化组62例（AACs≥5分）。血清CDC-42水平采用酶联免疫吸附试验进行检测。以中位血清CDC-42水平为界，划分为低CDC-42组56例和高CDC-42组56例。指标间的相关性采用Spearman相关性分析。MHD患者CDC-42升高和腹主动脉钙化的危险因素采用多因素Logistic回归分析进行探究，变量纳入采用进入法。应用线性回归分析探究指标间的多重共线性关系，血清CDC-42预测MHD患者腹主动脉钙化的临床价值应用受试者工作特征曲线进行评价。结果:112例患者中91例（81.25%，91/112）存在腹主动脉钙化，血清CDC-42水平为466.56（335.56，623.57）ng/L。无和轻度钙化组患者CDC-42、AACs、年龄、透析龄、糖尿病肾病比例、糖化血红蛋白、碱性磷酸酶、甲状旁腺激素及血钙分别为347.77（291.20，419.53）ng/L、1.00（0.00，3.00）分、（57.18±6.25）岁、31.50（15.00，49.25）个月、34.00%（17/50）、（6.63±0.97）%、116.22（87.32，152.13）U/L、258.57（143.40，433.31）ng/L、（2.18±0.26）mmol/L，中重度钙化组分别为602.69（489.61，762.73）ng/L、10.00（7.00，16.25）分、（60.81±7.12）岁、49.00（18.00，67.00）个月、53.23%（33/62）、（7.07±1.20）%、144.34（99.71，201.76）U/L、336.57（230.63，506.00）ng/L、（2.28±0.26）mmol/L，两组间比较差异均有统计学意义［统计量值分别为6.99、9.11、2.83、2.45、4.14、2.08、2.04、2.16、1.99，均n P<0.05］。低CDC-42组患者CDC-42、AACs、糖化血红蛋白及甲状旁腺激素分别为336.50（295.10，395.25）ng/L、2.00（0.00，4.00）分、（6.62±1.06）%、250.60（140.20，462.02）ng/L，高CDC-42组分别为622.92（558.11，836.65）ng/L、10.00（6.25，15.75）分、（7.13±1.13）%、347.21（240.40，501.20）ng/L，两组间比较差异均有统计学意义（统计量值分别为6.51、5.21、2.43、2.54，均n P<0.05）。腹主动脉钙化与患者血清CDC-42（n rn s=0.704，n P<0.001）、年龄（n rn s=0.308，n P=0.001）、透析龄（n rn s=0.198，n P=0.036）、糖化血红蛋白（n rn s=0.358，n P<0.001）、碱性磷酸酶（n rn s=0.187，n P=0.048）、甲状旁腺激素（n rn s=0.437，n P<0.001）、血钙（n rn s=0.323，n P=0.001）和血磷（n rn s=0.251，n P=0.007）均呈正相关性，与血清白蛋白水平呈负相关性（n rn s=-0.276，n P=0.003）。多因素Logistic回归分析结果表明，高CDC-42水平（n OR=1.010，n 95%CI：1.004~1.016，n P=0.001）和高透析龄（n OR=1.033，n 95%CI：1.006~1.061，n P=0.018）是MHD患者中重度腹主动脉钙化的独立危险因素。血清CDC-42水平与患者AACs（n rn s=0.704，n P<0.001）、年龄（n rn s=0.240，n P=0.011）、透析龄（n rn s=0.191，n P=0.044）、糖化血红蛋白（n rn s=0.350，n P<0.001）、甲状旁腺激素（n rn s=0.380，n P<0.001）和血钙（n rn s=0.235，n P=0.013）均呈正相关性。多因素Logistic回归分析结果表明，高AACs（n OR=1.185，95%n CI：1.037~1.354，n P=0.013）和高甲状旁腺激素（n OR=1.005，n 95%CI：1.001~1.009，n P=0.009）是MHD患者血清CDC-42升高的独立危险因素。血清CDC-42预测MHD患者中重度腹主动脉钙化的受试者工作特征曲线下面积为0.885，取截断值为466.56 ng/L，其预测的灵敏度为79%，特异度为86%。n 结论:MHD患者腹主动脉钙化程度与血清CDC-42水平呈正相关性，高血清CDC-42和高透析龄是MHD患者腹主动脉钙化的独立危险因素，高AACs和高甲状旁腺激素是MHD患者血清CDC-42升高的独立危险因素。“,”Objective:To explore the correlation between abdominal aortic calcification and serum cell division cycle 42 (CDC-42) in maintenance hemodialysis (MHD) patients, and to explore the influencing factors of them.Methods:A cross-sectional study was conducted in the Blood Purification Center of Qingdao Municipal Hospital,112 patients who underwent MHD for more than 6 months from October 2019 to March 2021 were selected. The abdominal aortic calcification score (ACCs) was calculated by reference to the abdominal lateral X flat tablets. According to AACS, 50 cases were divided into no and mild calcification group (0≤AACS<5 points) and 62 cases were divided into moderate and severe calcification group (AACS≥5 points). The level of serum CDC-42 was detected by enzyme linked immunosorbent assay (ELISA). Taking the median serum CDC-42 level as the boundary, 56 cases were divided into low CDC-42 group and high CDC-42 group. Spearman correlation analysis was used to analyze the correlation between indicators. The risk factors of elevated CDC-42 and abdominal aortic calcification in MHD patients were explored by multivariate logistic regression analysis, and the variables were included by entry method.Results:In 112 patients, 91 cases (81.25%, 91/112) had abdominal aortic calcification, and the median serum CDC-42 level was 466.56 (335.56,623.57) ng/L. CDC-42, AACs, age, dialysis age, diabetic nephropathy, glycosylated hemoglobin, alkaline phosphatase, parathormone and calcium in the no and mild calcification groups were 347.77 (291.20, 419.53) ng/L, 1.00 (0.00, 3.00) points, (57.18±6.25) years, 31.50 (15.00, 49.25) months, 34.00%(17/50), (6.63±0.97)%, 116.22 (87.32, 152.13) U/L, 258.57 (143.40, 433.31) ng/L, (2.18±0.26) mmol/L, and in the moderate to severe calcification group were 602.69 (489.61, 762.73) ng/L, 10.00 (7.00, 16.25) points, (60.81±7.12) years, 49.00 (18.00, 67.00) months, 53.23%(33/62), (7.07±1.20)%, 144.34 (99.71, 201.76) U/L, 336.57 (230.63, 506.00) ng/L,(2.28±0.26) mmol/L, with statistically significant differences between the two groups(The statistical values were 6.99, 9.11, 2.83, 2.45, 4.14, 2.08, 2.04, 2.16 and 1.99, respectively, all n P<0.05). CDC-42, AACs, glycosylated hemoglobin and parathormone in the low CDC-42 group were 336.50 (295.10, 395.25) ng/L, 2.00 (0.00, 4.00) points, (6.62±1.06) %, 250.60 (140.20, 462.02) ng/L,and in the high CDC-42 group were 622.92 (558.11, 836.65) ng/L, 10.00 (6.25, 15.75) points, (7.13±1.13) %, 347.21 (240.40,501.20) ng/L, with statistically significant differences between the two groups (The statistical values are 6.51, 5.21, 2.43 and 2.54, respectively,alln P<0.05). Abdominal aortic calcification has positive correlations with CDC-42 (n rn s=0.704, n P<0.001), age (n rn s=0.308, n P=0.001), dialysis years (n rn s=0.198, n P=0.036), glycosylated hemoglobin (n rn s=0.358, n P<0.001), alkaline phosphatase (n rn s=0.187, n P=0.048), parathormone (n rn s=0.437, n P<0.001), serum calciu m(n rn s=0.323, n P=0.001) and serum phospho-rus (n rn s=0.251, n P=0.007), and negative correlation with serum albumin(n rn s=-0.276, n P=0.003). This study has confirmed that high serum CDC-42 (n OR=1.010, n 95%CI:1.004-1.016, n P=0.001) and senior dialysis age (n OR=1.033, n 95%CI:1.006-1.061, n P=0.018) were independent risk factors for moderate to severe abdominal aortic calcification.Serum CDC-42 levels has positive correlation with AACs (n rn s=0.704, n P<0.001), age (n rn s=0.240, n P=0.011), dialysis age (n rn s=0.191, n P=0.044), glycosylated hemoglobin (n rn s=0.350, n P<0.001), parathormone (n rn s=0.380, n P<0.001) and serum calcium (n rn s=0.235, n P=0.013). This study learned that,high AACs (n OR=1.185, n 95%CI:1.037-1.354, n P=0.013) and high parathormone (n OR=1.005, n 95%CI:1.001-1.009, n P=0.009) were independent risk factors for high CDC-42. The area under the receiver operating characteristic curve (ROC-AUC) of serum CDC-42 in predicting moderate and severe abdominal aortic calcification in MHD patients was 0.885. When the cut-off point was 466.56 ng/L, the predictive sensitivity and specificity were 79% and 86% respectively.n Conclusion:The degree of abdominal aortic calcification in MHD patients was positively correlated with the level of serum CDC-42. High serum CDC-42 and high dialysis age were independent risk factors for abdominal aortic calcification in MHD patients. High AACS and high parathyroid hormone were independent risk factors for the increase of serum CDC-42 in MHD patientsn .