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目的:探讨不同血糖指标异常与妊娠期糖尿病孕妇妊娠结局的相关性。方法:选取我院产前检查的孕妇1000名,均为2013年4月至2014年4月收集,行75g葡萄糖耐量试验(OGTT),依据结果按血糖正常组及妊娠期糖尿病组划分,分析妊娠结局受不同血糖指标异常情况。结果:GDM组与正常对照组在FPG、HbAlc、VEGF值方面比较,有统计学差异(P<0.05)。VEGFR蛋白在胎盘组织中的表达量,相较正常对照组(0.051±0.019)及GDM围产儿正常组(0.128±0.048),GDM围产儿异常组居较高水平,为(0.275±0.086),有统计学差异(P<0.05)。结论:在GDM不良围产儿结局指标预测评估中,高VEGF价值确切,需引起临床高度重视,以明确诊断,及时救治,改善患者生存质量。
Objective: To investigate the relationship between abnormal glucose levels and pregnancy outcomes in gestational diabetes mellitus. Methods: A total of 1000 pregnant women were selected from our hospital for prenatal care. All of them were collected from April 2013 to April 2014, and 75g glucose tolerance test (OGTT) was performed. According to the results, normal pregnant women and gestational diabetes patients were divided according to the results, Outcome by different abnormalities in blood glucose indicators. Results: There were significant differences in FPG, HbAlc and VEGF between GDM group and normal control group (P <0.05). The expression of VEGFR protein in placenta was (0.275 ± 0.086) higher than that in normal control group (0.051 ± 0.019) and GDM perinatal normal group (0.128 ± 0.048) Statistical difference (P <0.05). Conclusion: In predicting and assessing the outcome of GDM with poor perinatal outcome, the value of high VEGF is accurate and needs to be paid more attention in clinic so as to confirm the diagnosis, treat it promptly and improve the quality of life of patients.