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目的探讨C反应蛋白(C-reative protein,CRP)对社区获得性肺炎(community acquired pneumonia,CAP)诊断的意义。方法选择2010年5月—2013年1月就诊的社区获得性肺炎患者59例,作为观察组,抽取同期进行体检的56例健康者作为对照组。于入院24 h内两组均清晨空腹抽取静脉血,分离血清,测定CRP、外周血WBC计数。同时,每日测量体温3～4次,取其平均值。CRP的正常上限为8 mg/L。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果观察组CRP>8 mg/L占94.9%,WBC>10×109/L占20.0%,体温>36.8℃占71.2%;对照组CRP、WBC、体温水平均正常。观察组CRP、WBC、体温水平分别为(47.97±19.37)mg/L、(10.00±2.17)×109/L、(38.24±0.57)℃,均高于对照组[(4.57±2.09)mg/L、(5.54±1.36)×109/L、(36.24±0.21)℃],比较差异均有统计学意义(t=16.671、13.126、24.709,均P<0.05)。结论 CRP可作为辅助诊断社区获得性肺炎的指标,为临床诊治提供依据。
Objective To investigate the significance of C-reactive protein (CRP) in the diagnosis of community-acquired pneumonia (CAP). Methods Fifty-nine patients with community-acquired pneumonia who were seen from May 2010 to January 2013 were selected as the observation group and 56 healthy people who took physical examinations during the same period were selected as the control group. Venous blood was drawn from the two groups in the morning 24 hours after admission, serum was separated, and CRP and peripheral WBC count were measured. At the same time, daily body temperature measurement 3 to 4 times, whichever is the average. The normal upper limit for CRP is 8 mg / L. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The CRP> 8 mg / L in the observation group accounted for 94.9%, the WBC> 10 × 109 / L accounted for 20.0%, and the body temperature> 36.8 ℃ accounted for 71.2%. The CRP, WBC and body temperature in the control group were all normal. The levels of CRP, WBC and body temperature in the observation group were (47.97 ± 19.37) mg / L and (10.00 ± 2.17) × 109 / L and (38.24 ± 0.57) ℃, respectively, higher than those in the control group [(4.57 ± 2.09) mg / L , (5.54 ± 1.36) × 109 / L, (36.24 ± 0.21) ℃] respectively. There were significant differences between the two groups (t = 16.671,13.126,24.709, all P <0.05). Conclusion CRP can be used as an auxiliary diagnosis of community-acquired pneumonia indicators, provide a basis for clinical diagnosis and treatment.