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目的：比较细胞粘附分子ICAM－1、VCAM－1和ELAM－1在皮肤白细胞碎裂性和淋巴细胞性血管炎的表达及其意义。方法：采用免疫级化方法研究两型血管炎的粘附分子表达情况。结果：角质形成细胞ICAM－1在淋巴细胞性血管炎（85.71％）表达明显高于白细胞碎裂性血管炎（11．11％）（p＜0．0001）．ICAM－1、VCAM－1、ELAM－1在两型血管炎血管内皮中表达无区别（P值分别为1，0．0680．46）。结论：无论在白细胞碎裂性还是淋巴细胞性血管炎，粘附分子表达均上调。两种血管炎粘附分子表达率的不同反应了局部细胞因子释放的不同，这对揭示血管炎发病机理将具有重要意义。
OBJECTIVE: To compare the expression of ICAM-1, VCAM-1 and ELAM-1 on skin leukocyte fragmentation and lymphocytic vasculitis and their significance. Methods: Immuno-grade method was used to study the expression of adhesion molecules in two types of vasculitis. Results: The expression of ICAM-1 in keratinocytes was significantly higher in lymphocytic vasculitis (85.71%) than that in leukopenia (11.11%) (p <0.0001). The expression of ICAM-1, VCAM-1 and ELAM-1 was no difference between the two types of vasculitis vascular endothelial cells (P values were 1,0.0680.46). Conclusion: Both leukocyte fragmentation and lymphocytic vasculitis upregulate the expression of adhesion molecules. The difference in the expression rates of the two vasculitic adhesion molecules reflects the differences in the release of local cytokines, which is of great importance for revealing the pathogenesis of vasculitis.