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目前临床上诊断移植肾急性排斥反应(acute rejection,AR)的方法主要包括临床表现、肾功能检查(主要为血肌酐)及移植肾穿刺活检。然而临床表现缺乏特异性。血肌酐是目前移植肾发生AR最初可观察到的指标,但是它缺乏特别的灵敏性和特异性,常需要随之的肾穿刺活检来证实;其次它不能反映早期AR,只有当AR严重到损害肾功能时血
At present, the methods of clinical diagnosis of acute rejection of renal allografts include clinical manifestations, renal function tests (mainly serum creatinine) and transplanted renal biopsy. However, the clinical manifestations of the lack of specificity. Serum creatinine is the first observable indicator of renal AR, but it lacks particular sensitivity and specificity and often needs to be confirmed by renal biopsy. Second, it does not reflect early AR only if AR is severe enough to cause damage Kidney function when the blood