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目的观察戊酸雌二醇联合黄体酮序贯治疗对功能性子宫出血患者的临床疗效。方法 64例功能性子宫出血患者随机分为对照组32例和试验组32例。对照组口服戊酸雌二醇治疗,起始剂量为每次6 mg,每天3次,出血减少时减量,直至每次1 mg维持,持续21 d。试验组在此基础上10 d后口服黄体酮10mg·d~(-1)。2组均治疗3个月经周期。观察治疗前后患者出血时间、停药后的排卵恢复的情况及下次月经量的改变。结果治疗后,试验组控制出血时间为(25.33±0.52)h,对照组为(32.27±0.80)h(P<0.05)。试验组患者的完全止血时间为(40.68±0.82)h,对照组为(51.85±1.10)h(P<0.05)。试验组患者的住院时间为(80.50±1.56)h,对照组为(119.40±1.76)h(P<0.05)。试验组23例患者恢复排卵,对照组14例恢复排卵,差异有统计学意义(P<0.05)。试验组月经量大于80 m L的患者为4例,对照组月经量大于80 m L的患者为4例,差异无统计学意义(P>0.05)。2组在治疗过程中均无明显的药物不良反应发生。结论戊酸雌二醇联合黄体酮序贯疗法可以有效改善功能性子宫出血患者的症状,促进排卵恢复。
Objective To observe the clinical efficacy of sequential administration of valerate valerate and progesterone in patients with functional uterine bleeding. Methods Sixty-four patients with functional uterine bleeding were randomly divided into control group (32 cases) and experimental group (32 cases). Control group oral estradiol valerate treatment, the initial dose of 6 mg each time, 3 times a day, reduce the amount of bleeding reduced until each 1 mg maintained for 21 d. On the basis of this, the experimental group received 10 mg · d ~ (-1) of progesterone orally after 10 days. 2 groups were treated 3 menstrual cycle. Observe the bleeding time before and after treatment, ovulation recovery after withdrawal and the next menstrual flow changes. Results After treatment, the bleeding time in the experimental group was (25.33 ± 0.52) h and in the control group (32.27 ± 0.80) h (P <0.05). The complete bleeding time was (40.68 ± 0.82) h in the test group and (51.85 ± 1.10) h in the control group (P <0.05). The hospitalization time was (80.50 ± 1.56) h in the test group and (119.40 ± 1.76) h in the control group (P <0.05). Ovulation was restored in 23 patients in the experimental group and ovulation in 14 patients in the control group. The difference was statistically significant (P <0.05). Four patients in the test group had menstrual flow greater than 80 m L, and four patients in the control group had more than 80 m L of menstrual flow. The difference was not statistically significant (P> 0.05). Two groups in the course of treatment were no obvious adverse drug reactions. Conclusion Sequential administration of estradiol valerate combined with progesterone can effectively improve the symptoms of patients with functional uterine bleeding and promote ovulation recovery.