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药物高敏感性或过敏与药物剂量大小无关,而且可以发生于药物治疗期间的任何时候。虽然近期报告有长期反应的病例,一般于停药后症状即可消退。相反的,中毒性心肌炎则与药物剂量有关。即使停药后其毒性作用仍继续。Billingham总结了这两种心肌炎病理上的差异。药物高敏感性心肌炎时有嗜伊红细胞,非典型淋巴细胞和巨细胞,而无成纤维细胞或纤维变性。这些病理损伤都同期出现,而且可伴有肉芽肿浸润和非坏死性血管炎。中毒性心肌炎的病理损伤可不同时期出现,无嗜伊红细胞,无巨细胞,淋巴细胞正常,而有成纤维细胞和纤维变性,并伴坏死性血管炎。
Drug hypersensitivity or allergy does not depend on the size of the drug and can occur at any time during drug treatment. Although recent reports of long-term response to the case, the symptoms usually subsided after withdrawal. In contrast, toxic myocarditis is related to the dose of the drug. Even after discontinuation of its toxic effects continue. Billingham summarizes the pathological differences between the two types of myocarditis. Drug hypersensitivity myocarditis with eosinophils, atypical lymphocytes and giant cells, and no fibroblasts or fibrosis. These pathological lesions occur simultaneously, and may be associated with infiltration of granulomas and non-necrotic vasculitis. Toxic myocarditis pathological damage can occur at different times, no eosinophils, no giant cells, normal lymphocytes, and fibroblasts and fibrosis, and necrotizing vasculitis.