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目的研究肺炎支原体感染患儿血清IL-17、IL-23表达水平变化及临床意义。方法用ELISA法检测肺炎支原体感染患儿血清IL-17、IL-23含量,对MPIgM抗体阳性和MPIgM、IgG抗体同为阳性患儿以及对照组间血清IL-17、IL-23含量比较,对不同临床症状患儿以及对照组血清IL-17、IL-23含量间进行比较,并进行统计学分析。结果 MPIgM抗体阳性和MPIgM、IgG抗体同为阳性患儿血清IL-17、IL-23含量比对照组显著升高(P<0.01),它们之间比较差异也有统计学意义(P<0.01);MP感染患儿中上呼吸道感染、MPP患儿血清IL-17、IL-23含量比对照组显著升高(P<0.01),它们之间比较差异也有统计学意义(P<0.01);MPP中不同临床症状的患儿间血清IL-17、IL-23含量差异有统计学意义(P<0.01)。结论血清IL-17、IL-23含量变化可能促进MP感染患儿的不同临床表现,检测MP感染患儿血清IL-17、IL-23含量对了解疾病的进展和疗效,对MPP治疗有一定的临床意义。
Objective To study the changes of serum IL-17 and IL-23 in children with Mycoplasma pneumoniae infection and its clinical significance. Methods Serum levels of IL-17 and IL-23 in children with Mycoplasma pneumoniae infection were detected by ELISA. The levels of IL-17 and IL-23 in children with positive MPIgM antibody, MPIgM, IgG antibody positive children and control group were compared Serum levels of IL-17 and IL-23 in children with different clinical symptoms and controls were compared and statistically analyzed. Results Compared with the control group, the levels of IL - 17 and IL - 23 in the MPIgM positive and MPIgM and IgG positive children were significantly higher than those in the control group (P <0.01). There was also a significant difference between them (P <0.01). MP infection in children with upper respiratory tract infection, MPP children with serum IL-17, IL-23 levels were significantly higher than the control group (P <0.01), and the difference between them was also statistically significant (P <0.01); MPP The serum IL-17 and IL-23 levels in children with different clinical symptoms were significantly different (P <0.01). Conclusion The changes of serum IL-17 and IL-23 levels may promote the different clinical manifestations in children with MP infection. To detect the serum IL-17 and IL-23 levels in children with MP infection to understand the progress of the disease and the curative effect of MPP treatment Clinical significance.