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患者,女,35岁。因患感冒,头昏、鼻塞而自行服用复方苯丙醇胺(康泰克)胶囊,用法为一次1颗,2次/d,未合用其他任何药物,第2次服药后,病人即感到手指出现麻木、抖动,但不影响日常生活,因病情症状好转而停药,手指抖动也逐渐消失。在1个月后,又由于鼻塞、流鼻涕而服用复方苯丙醇胺胶囊,次日,出现手指麻木,四肢不由自主抖动,遂来医院就诊。体检:神志清,颈软,发音清,无面瘫,伸舌正中,双侧瞳孔等大,眼球无震颤。四肢呈节律性抖动,肌张力增高,站立时头部前倾,肝功能及眼底检查正常。诊断为“帕金森征”。停用复方苯丙醇胺胶囊,给予口服苯海索片每次4mg,3次/d、第2d症状消失,停用苯海索,症状未再出现。证实为复方苯丙醇胺所致。 复方苯丙醇胺是由盐酸苯丙醇和扑尔敏组成的复方缓释制剂,用于感冒早期的治疗,疗效显著。随着药品用量的增加,各种不良反应也时有报道,而引起帕金森征则少见。本例应用复方苯丙醇胺后,引
Patient, female, 35 years old. Due to a cold, dizziness, nasal congestion and taking their own compound phenylpropanolamine (CONTEX) capsule, the use of a 1, 2 times / d, not combined with any other drug, the second medication, the patient felt the finger that appears Numbness, jitter, but does not affect daily life, withdrawal due to the improvement of the symptoms, finger jitter also gradually disappear. In a month later, due to nasal congestion, runny nose and taking compound phenylpropanolamine capsules, the next day, finger numbness, limbs involuntarily jitter, then came to the hospital. Physical examination: clear mind, neck soft, clear pronunciation, no facial paralysis, extending tongue middle, bilateral pupils and other large, no tremor of the eye. Rhythms of limbs jitter, muscle tension increased, standing head anteversion, liver function and fundus examination was normal. Diagnosed as “Parkinson’s sign.” Compound phenylpropanolamine capsules were discontinued, given oral diphenhydramine tablets 4mg, 3 times / d, the first 2d symptoms disappear, disable benzene hydroxyzole, the symptoms no longer appear. Confirmed as compound phenylpropanolamine caused. Phenylpropanolamine is a compound sustained-release preparation composed of phenylpropanol hydrochloride and chlorpheniramine, which is used for the early cold treatment and has a remarkable curative effect. With the increase in the amount of drugs, a variety of adverse reactions are also reported from time to time, while causing Parkinson’s syndrome is rare. In this case, after the application of phenylpropanolamine, cited